| 1 |  Eli Lilly and CompanyLLY | Pharmaceutical Preparations | $1.070 T |
| 2 |  Johnson & JohnsonJNJ | Pharmaceutical Preparations | $574.10 B |
| 3 |  AbbVie Inc.ABBV | Pharmaceutical Preparations | $397.44 B |
| 4 |  Merck & Co., Inc.MRK | Pharmaceutical Preparations | $294.13 B |
| 5 |  AstraZeneca PLCAZN | Pharmaceutical Preparations | $286.27 B |
| 6 |  Novartis AGNVS | Pharmaceutical Preparations | $282.64 B |
| 7 |  GSK plcGSK | Pharmaceutical Preparations | $220.82 B |
| 8 |  Novo Nordisk A/SNVO | Pharmaceutical Preparations | $202.94 B |
| 9 |  Abbott LaboratoriesABT | Pharmaceutical Preparations | $155.32 B |
| 10 |  Pfizer Inc.PFE | Pharmaceutical Preparations | $145.91 B |
| 11 |  Bristol-Myers Squibb CompanyBMY | Pharmaceutical Preparations | $113.54 B |
| 12 |  Vertex Pharmaceuticals IncorporatedVRTX | Pharmaceutical Preparations | $110.59 B |
| 13 |  Regeneron Pharmaceuticals, Inc.REGN | Pharmaceutical Preparations | $56.80 B |
| 14 |  SanofiSNY | Pharmaceutical Preparations | $53.13 B |
| 15 |  Teva Pharmaceutical Industries LimitedTEVA | Pharmaceutical Preparations | $39.10 B |
| 16 |  Alnylam Pharmaceuticals, Inc.ALNY | Pharmaceutical Preparations | $38.62 B |
| 17 |  Zoetis Inc.ZTS | Pharmaceutical Preparations | $34.08 B |
| 18 | OBeOne Medicines AGONC | Pharmaceutical Preparations | $32.14 B |
| 19 |  Takeda Pharmaceutical Company LimitedTAK | Pharmaceutical Preparations | $24.43 B |
| 20 | UUnited Therapeutics CorporationUTHR | Pharmaceutical Preparations | $23.10 B |
| 21 | RRoyalty Pharma plcRPRX | Pharmaceutical Preparations | $21.16 B |
| 22 |  Roivant Sciences Ltd.ROIV | Pharmaceutical Preparations | $20.43 B |
| 23 | IInsmed IncorporatedINSM | Pharmaceutical Preparations | $19.92 B |
| 24 |  Viatris Inc.VTRS | Pharmaceutical Preparations | $18.36 B |
| 25 | GGenmab A/SGMAB | Pharmaceutical Preparations | $16.27 B |
| 26 |  Jazz Pharmaceuticals plcJAZZ | Pharmaceutical Preparations | $14.41 B |
| 27 |  BridgeBio Pharma, Inc.BBIO | Pharmaceutical Preparations | $13.20 B |
| 28 | AAscendis Pharma A/SASND | Pharmaceutical Preparations | $13.00 B |
| 29 |  Axsome Therapeutics, Inc.AXSM | Pharmaceutical Preparations | $12.68 B |
| 30 | IIonis Pharmaceuticals, Inc.IONS | Pharmaceutical Preparations | $12.12 B |
| 31 |  Elanco Animal Health IncorporatedELAN | Pharmaceutical Preparations | $11.42 B |
| 32 |  Dr. Reddy's Laboratories LimitedRDY | Pharmaceutical Preparations | $11.10 B |
| 33 | MMadrigal Pharmaceuticals, Inc.MDGL | Pharmaceutical Preparations | $10.87 B |
| 34 |  BioMarin Pharmaceutical Inc.BMRN | Pharmaceutical Preparations | $10.86 B |
| 35 |  Summit Therapeutics Inc.SMMT | Pharmaceutical Preparations | $10.13 B |
| 36 |  Arrowhead Pharmaceuticals, Inc.ARWR | Pharmaceutical Preparations | $9.96 B |
| 37 | NNuvalent, Inc.NUVL | Pharmaceutical Preparations | $8.64 B |
| 38 |  Corcept Therapeutics IncorporatedCORT | Pharmaceutical Preparations | $8.39 B |
| 39 |  Cytokinetics, IncorporatedCYTK | Pharmaceutical Preparations | $8.35 B |
| 40 | AABIVAX Société AnonymeABVX | Pharmaceutical Preparations | $7.70 B |
| 41 |  Alkermes plcALKS | Pharmaceutical Preparations | $7.31 B |
| 42 |  TG Therapeutics, Inc.TGTX | Pharmaceutical Preparations | $7.14 B |
| 43 | PProtagonist Therapeutics, Inc.PTGX | Pharmaceutical Preparations | $6.80 B |
| 44 |  Grifols, S.A.GRFS | Pharmaceutical Preparations | $6.77 B |
| 45 | PPraxis Precision Medicines, Inc.PRAX | Pharmaceutical Preparations | $6.71 B |
| 46 | SSpyre Therapeutics, Inc.SYRE | Pharmaceutical Preparations | $6.52 B |
| 47 | CCentessa Pharmaceuticals plcCNTA | Pharmaceutical Preparations | $6.14 B |
| 48 |  Terns PharmaceuticalsTERN | Pharmaceutical Preparations | $6.12 B |
| 49 |  PTC Therapeutics, Inc.PTCT | Pharmaceutical Preparations | $6.03 B |
| 50 |  Rhythm Pharmaceuticals, Inc.RYTM | Pharmaceutical Preparations | $5.87 B |
| 51 |  Liquidia CorporationLQDA | Pharmaceutical Preparations | $5.80 B |
| 52 |  Mirum Pharmaceuticals, Inc.MIRM | Pharmaceutical Preparations | $5.73 B |
| 53 | BBelite Bio, IncBLTE | Pharmaceutical Preparations | $5.37 B |
| 54 | CCogent Biosciences, Inc.COGT | Pharmaceutical Preparations | $5.36 B |
| 55 | AApellis PharmaceuticalsAPLS | Pharmaceutical Preparations | $5.25 B |
| 56 |  Legend Biotech CorporationLEGN | Pharmaceutical Preparations | $5.04 B |
| 57 | LLigand Pharmaceuticals IncorporatedLGND | Pharmaceutical Preparations | $4.97 B |
| 58 | XXenon Pharmaceuticals Inc.XENE | Pharmaceutical Preparations | $4.96 B |
| 59 |  Amneal Pharmaceuticals, Inc.AMRX | Pharmaceutical Preparations | $4.89 B |
| 60 |  Indivior PLCINDV | Pharmaceutical Preparations | $4.64 B |
| 61 |  Amicus TherapeuticsFOLD | Pharmaceutical Preparations | $4.55 B |
| 62 | TTravere Therapeutics, Inc.TVTX | Pharmaceutical Preparations | $4.35 B |
| 63 | DDianthus Therapeutics, Inc.DNTH | Pharmaceutical Preparations | $4.18 B |
| 64 | EErasca, Inc.ERAS | Pharmaceutical Preparations | $4.16 B |
| 65 | TTango Therapeutics, Inc.TNGX | Pharmaceutical Preparations | $4.15 B |
| 66 | MVeradermics, IncorporatedMANE | Pharmaceutical Preparations | $3.88 B |
| 67 | OOruka Therapeutics, Inc.ORKA | Pharmaceutical Preparations | $3.86 B |
| 68 |  Catalyst Pharmaceuticals, Inc.CPRX | Pharmaceutical Preparations | $3.84 B |
| 69 | KKiniksa Pharmaceuticals International, plcKNSA | Pharmaceutical Preparations | $3.75 B |
| 70 |  ACADIA Pharmaceuticals Inc.ACAD | Pharmaceutical Preparations | $3.64 B |
| 71 | CCrinetics Pharmaceuticals, Inc.CRNX | Pharmaceutical Preparations | $3.62 B |
| 72 | EEdgewise Therapeutics, Inc.EWTX | Pharmaceutical Preparations | $3.54 B |
| 73 |  Organon & Co.OGN | Pharmaceutical Preparations | $3.51 B |
| 74 | NNewAmsterdam Pharma Company N.V.NAMS | Pharmaceutical Preparations | $3.43 B |
| 75 |  Viking Therapeutics, Inc.VKTX | Pharmaceutical Preparations | $3.22 B |
| 76 |  Telix Pharmaceuticals LimitedTLX | Pharmaceutical Preparations | $3.20 B |
| 77 |  Dyne Therapeutics, Inc.DYN | Pharmaceutical Preparations | $2.92 B |
| 78 | AArcutis Biotherapeutics, Inc.ARQT | Pharmaceutical Preparations | $2.91 B |
| 79 | GStructure Therapeutics Inc.GPCR | Pharmaceutical Preparations | $2.81 B |
| 80 |  Arcus Biosciences, Inc.RCUS | Pharmaceutical Preparations | $2.78 B |
| 81 | SSoleno TherapeuticsSLNO | Pharmaceutical Preparations | $2.76 B |
| 82 | AAlumis Inc.ALMS | Pharmaceutical Preparations | $2.74 B |
| 83 | SSupernus Pharmaceuticals, Inc.SUPN | Pharmaceutical Preparations | $2.62 B |
| 84 | IDisc Medicine, Inc.IRON | Pharmaceutical Preparations | $2.57 B |
| 85 | KKailera Therapeutics, Inc.KLRA | Pharmaceutical Preparations | $2.48 B |
| 86 | IIDEAYA Biosciences, Inc.IDYA | Pharmaceutical Preparations | $2.42 B |
| 87 |  Prestige Consumer Healthcare Inc.PBH | Pharmaceutical Preparations | $2.33 B |
| 88 | VVera Therapeutics, Inc.VERA | Pharmaceutical Preparations | $2.27 B |
| 89 | RUltragenyx Pharmaceutical Inc.RARE | Pharmaceutical Preparations | $2.26 B |
| 90 | EEnliven Therapeutics, Inc.ELVN | Pharmaceutical Preparations | $2.25 B |
| 91 | DDay One BiopharmaceuticalsDAWN | Pharmaceutical Preparations | $2.22 B |
| 92 | PPhibro Animal Health CorporationPAHC | Pharmaceutical Preparations | $2.16 B |
| 93 |  HUTCHMED (China) LimitedHCM | Pharmaceutical Preparations | $2.08 B |
| 94 | IImmunome, Inc.IMNM | Pharmaceutical Preparations | $2.06 B |
| 95 | PPharvaris N.V.PHVS | Pharmaceutical Preparations | $2.05 B |
| 96 | HHarmony Biosciences Holdings, Inc.HRMY | Pharmaceutical Preparations | $2.05 B |
| 97 | AAurinia Pharmaceuticals Inc.AUPH | Pharmaceutical Preparations | $2.01 B |
| 98 |  Zai Lab LimitedZLAB | Pharmaceutical Preparations | $2.00 B |
| 99 | MMineralys Therapeutics, Inc.MLYS | Pharmaceutical Preparations | $1.96 B |
| 100 |  Bausch Health Companies Inc.BHC | Pharmaceutical Preparations | $1.92 B |